🧬 Regenerative Medicine · DABRM Certified · Secunderabad

OrthoRegenβ„’

Healing damaged joints using the body's own biology β€” without surgery, without steroids, without side effects.

"Your body already knows how to heal. We just give it the right tools."

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The Problem with Conventional Options

Why Regenerative Medicine Changes Everything

πŸ’Š

Painkillers Don't Heal

Anti-inflammatory tablets and cortisone injections mask pain β€” they do not repair damaged cartilage. With repeated use, cortisone actually accelerates cartilage breakdown. You feel better, but the joint gets worse.

πŸ”ͺ

Surgery Has Risks

Joint replacement is a major operation with real risks β€” anaesthesia, infection, blood clots, implant loosening. It should be the last option β€” not the default answer for Grade 1-3 arthritis.

🧬

Your Body CAN Repair

Cartilage has poor blood supply β€” that's why it heals slowly. Regenerative therapy delivers concentrated healing signals directly to the damaged area, bypassing this limitation and triggering genuine repair.

Dr. Sumit's Analogy

The Construction Crew Inside Your Blood

Think of your joint as a building that has developed cracks. Your blood naturally sends a few repair workers β€” but not enough to fix major damage.

Regenerative therapy is like calling 10x more skilled workers β€” with the exact tools needed β€” directly to the site of damage. They work faster, in higher numbers, and with better equipment than what your body sends on its own.

🏚️
Damaged Joint
β†’
πŸ—οΈ
Repair Initiated
β†’
🏠
Restored Joint
Normal healing
πŸ‘· Γ— 3 workers
With Regen Therapy
πŸ‘·πŸ‘·πŸ‘·πŸ‘·πŸ‘·πŸ‘·πŸ‘·πŸ‘·πŸ‘·πŸ‘·
Γ— 10-30x more healing signals
🩸

PRP β€” Platelet Rich Plasma

Most Commonly Used Β· Grade 1-3 OA
🧠 Simple Analogy β€” How to Think About PRP

Think of your blood as a river carrying construction workers called platelets. Each platelet carries tiny packets of repair instructions called growth factors β€” like building materials. Normally, when your joint is damaged, only a few workers reach the site. PRP concentrates these workers 5-7 times and injects them exactly where the damage is β€” like calling an entire construction crew to one specific pothole instead of the whole city.

βš™οΈ How PRP is Made

1

Blood Draw β€” 30ml from your arm (same as a routine blood test)

2

Centrifuge β€” Blood spun at high speed. Red cells sink to bottom. Platelets concentrate at top

3

Collect PRP Layer β€” The platelet-rich layer is carefully collected. 5-7x more concentrated than normal blood

4

Inject β€” Under ultrasound guidance, directly into the damaged joint or tendon

βœ“

Done β€” Go home same day. No hospital. No surgery.

πŸ”¬ What Happens in the Centrifuge

After Spinning
🩸 PRP Layer 5-7x concentrated
🟑 Plasma layer discarded
πŸ”΄ Red Blood Cells discarded
Growth factors in PRP: PDGF, TGF-Ξ², VEGF, IGF-1, EGF β€” these are your body's natural repair signals delivered in concentrated form.

πŸ’‰ Cortisone Injection

  • βœ“ Works fast (3-5 days)
  • βœ— Does NOT repair β€” only masks pain
  • βœ— Damages cartilage with repeated use
  • βœ— Effect lasts only 4-8 weeks
  • βœ— Raises blood sugar (bad for diabetics)
  • βœ— Weakens tendons with repeat injections
VS

🩸 PRP Injection

  • ~ Takes 4-6 weeks to show effect
  • βœ“ Actually repairs damaged tissue
  • βœ“ DOES NOT damage cartilage
  • βœ“ Effect lasts 12-18 months
  • βœ“ Safe for diabetics
  • βœ“ Strengthens tendons
70-80%

Patients with Grade 1-3 OA report significant pain reduction at 6 months

12-18

Months the effects typically last before repeat injection is needed

3

Injections in a series for knee OA, spaced 4-6 weeks apart

βœ… PRP Works Best For:

Grade 1-3 Knee OA Partial Rotator Cuff Tear Tennis / Golfer's Elbow Plantar Fasciitis Early Hip Arthritis Achilles Tendinopathy ❌ NOT for Grade 4 (bone on bone)
🦴

BMAC β€” Bone Marrow Aspirate Concentrate

Most Powerful Β· Grade 2-3 OA Β· AVN
🧠 Simple Analogy β€” How to Think About BMAC

Your bone marrow is like a stem cell factory β€” a place deep inside your pelvic bone that continuously produces master cells capable of becoming cartilage, bone, or muscle. PRP uses repair workers from your blood. BMAC goes straight to the factory β€” harvesting stem cells in concentrated form and delivering them directly to the damaged joint. These stem cells do not just send repair signals β€” they can physically transform into new cartilage cells.

βš™οΈ How BMAC is Done

1

Local anaesthesia to the back of the pelvis. Patient awake, no general anaesthesia

2

Bone marrow aspiration β€” 30-60ml drawn from the iliac crest (pelvis). Minor discomfort, not severe pain

3

Centrifuge processing β€” Stem cells concentrated 5-10x. Growth factors retained

4

Image-guided injection β€” Under fluoroscopy or ultrasound, directly into the joint

βœ“

Same-day procedure β€” Walking within hours. Home the same day

πŸ”¬ PRP vs BMAC β€” What's the Difference?

🩸 PRP β€” from BLOOD

Contains platelets + growth factors. Reduces inflammation, activates healing signals. Does not generate new cells.

🦴 BMAC β€” from BONE MARROW

Contains mesenchymal stem cells + growth factors. Reduces inflammation AND can physically generate new cartilage cells. More powerful for actual tissue repair.

Bottom line: PRP signals repair. BMAC signals repair AND can create new tissue. For significant cartilage damage, BMAC is the more powerful option.

🦴 Special Use: BMAC + Core Decompression for AVN

Avascular Necrosis (AVN) of the hip is a condition where the blood supply to the femoral head is cut off β€” the bone begins to die. When caught early (Stage 1-2), combining BMAC with Core Decompression (drilling small tunnels to restore blood supply) can prevent femoral head collapse and potentially avoid hip replacement completely. This is one of the most impactful uses of regenerative medicine in orthopaedics.

3-5

Years duration of BMAC effect in multiple published studies

Single

Procedure usually sufficient. No repeat visits needed

Grade
2-3

Optimal for significant cartilage damage not responding to PRP

βœ… BMAC Works Best For:

Grade 2-3 Knee OA Cartilage Defects Early AVN of Hip Young Active Patients Failed PRP Cases ❌ NOT for Grade 4 (bone on bone)
πŸ’›

MFAT β€” Micro-Fragmented Adipose Tissue

Fat-Derived Stem Cells Β· Moderate-Severe OA
🧠 Simple Analogy β€” How to Think About MFAT

Most people think of fat as just stored energy. But your fat tissue is actually packed with stem cells β€” called ADSCs (Adipose-Derived Stem Cells) β€” and powerful anti-inflammatory molecules. MFAT is like taking a small piece of your fat (from the abdomen β€” only 60-100ml, tiny amount), micro-shredding it into tiny fragments, and injecting it into the joint. The fat matrix acts as a biological scaffold β€” stem cells settle in, send out healing signals, modulate inflammation, and the joint begins repairing from within. It's like laying down a healing foundation inside the joint.

βš™οΈ The MFAT Procedure

1

Local anaesthesia to the abdomen. No general anaesthesia required

2

Micro-lipoaspiration β€” 60-100ml fat removed from abdomen (comparable to a lipstick cap in volume)

3

Lipogems processing β€” Fat passed through special filtering device. No lab, no centrifuge needed. Produces micro-fragmented fat

4

Injection β€” Under ultrasound guidance into the joint. Fat fragments settle as a biological scaffold

βœ“

Under 90 minutes total β€” Same day. No hospital stay.

πŸ”¬ What's Inside Fat Tissue?

πŸ’› Adipose-Derived Stem Cells (ADSCs)

Can differentiate into cartilage, bone, and other tissues. More abundant in fat than bone marrow.

🌿 Anti-Inflammatory Molecules

IL-10, TGF-Ξ² β€” powerful inflammation modulators. Particularly effective for inflammatory arthritis.

πŸ—οΈ Stromal Vascular Fraction (SVF)

The scaffold β€” supports stem cell attachment and function in the joint.

Key advantage: MFAT contains 500x more stem cells per ml than bone marrow.

πŸ’‘ When to Choose MFAT over PRP or BMAC

CHOOSE PRP WHEN

Grade 1-2 OA, tendon problems, early disease, first treatment attempt

CHOOSE BMAC WHEN

Grade 2-3, cartilage defects, AVN, young active patient

CHOOSE MFAT WHEN

Moderate-severe OA, failed PRP, inflammatory arthritis, multiple joints

500x

More stem cells per ml in fat compared to bone marrow

2-4

Years expected duration of benefit from single MFAT procedure

<90

Minutes β€” total procedure time from start to finish

βœ… MFAT Works Best For:

Moderate-Severe OA (Grade 2-4) Failed PRP Cases Rheumatoid Arthritis Flares Multiple Joint Involvement Patients with Good Abdominal Fat
🌱

Allogenic Stem Cell Therapy

Donor Cells Β· Elderly Patients Β· Inflammatory Arthritis
🧠 Simple Analogy β€” How to Think About Allogenic Therapy

In PRP, BMAC, and MFAT β€” we use YOUR OWN cells (autologous). In allogenic therapy, we use stem cells donated by young, healthy donors β€” processed, tested, and ready to use like a medicine. Think of it like a blood transfusion β€” but instead of blood, we transfuse young, powerful repair cells. These donor cells come from umbilical cord blood or young bone marrow donors. The remarkable thing? These cells are immunoprivileged β€” they do not trigger rejection like organ transplants do. They release healing signals, modulate the immune system, and reduce inflammation β€” then naturally disappear from the body.

βš™οΈ How Allogenic Therapy Works

1

Ready-to-use vials β€” No harvesting from the patient. Cells come from screened, tested young donors

2

Simple injection β€” Administered directly into the joint under image guidance

3

Donor MSCs release growth factors β€” Modulate inflammation, signal cartilage repair

4

Immunoprivileged property β€” Cells are not rejected by the patient's immune system

5

Can combine with PRP for enhanced synergistic effect

πŸ”¬ Autologous vs Allogenic

🧬 Autologous (PRP, BMAC, MFAT)

Uses YOUR own cells. No rejection risk. Cell quality depends on your age and health. Harvesting procedure required.

🌱 Allogenic (Donor Stem Cells)

Uses YOUNG DONOR cells. No harvesting from patient. Excellent for elderly with poor own cell quality. No rejection due to immunoprivilege property.

⚠️ Evidence Note

Allogenic therapy currently has Level 2-3 evidence. More promising than experimental but less proven than PRP/BMAC. Dr. Sumit offers this selectively with full honest counselling.

πŸ‘¨β€βš•οΈ

Dr. Sumit's Position on Allogenic Therapy

"I have seen patients spend lakhs at clinics promising guaranteed results from allogenic stem cells. The truth is β€” the evidence is still emerging. I offer allogenic therapy selectively: when the patient cannot undergo their own cell harvesting, when autologous options have been exhausted, or when the inflammatory profile specifically warrants it. I will always tell you honestly what the evidence level is for any treatment I recommend. That honesty is non-negotiable."

β€” Dr. Sumit Dubewar, DABRM (USA)

βœ… Allogenic Therapy is Best For:

Elderly (poor own cell quality) Failed Autologous Treatments Severe Inflammatory Arthritis Cannot Undergo Harvesting Multiple Joint Disease
How We Decide

The OrthoRegenβ„’ Treatment Pathway

Surgery is always the last option. Not the first.

1

Lifestyle + Physiotherapy

Weight management, targeted exercises, activity modification. Reduces knee load by 20-40%. First step for every grade.

All Grades Β· No cost Β· Start today
2

PRP Therapy

Grade 1-3. 3 injections over 12 weeks. Anti-inflammatory + cartilage activation. Outperforms cortisone at 12 months.

Grade 1-3 Β· Day procedure Β· 3 sessions
3

BMAC or MFAT

Grade 2-3 with cartilage defects. Single procedure. Stem cells + scaffold. Most powerful autologous option.

Grade 2-3 Β· Single procedure Β· 3-5 years
4

Allogenic Stem Cell

When autologous options unsuitable. Elderly patients. Inflammatory conditions. Always with honest evidence counselling.

Selected cases only Β· Evidence Level 2-3
5

Joint Replacement Surgery

Grade 4 only β€” bone on bone with no cartilage remaining. When all other options have been tried. Robotic precision for best outcome.

Grade 4 only Β· Last resort Β· Excellent outcome when needed
πŸŽ“

Why Choose Dr. Sumit for Regenerative Treatment?

Dr. Sumit holds the DABRM (Diplomate, American Board of Regenerative Medicine) β€” one of very few orthopedic surgeons in India with this US certification. This means his protocols are based on published international evidence β€” not trends, not marketing. Every treatment recommendation comes with honest counselling about what the evidence says, what to realistically expect, and what the alternatives are.

MBBS Β· DNB DABRM (USA) FIJR Β· FIASM Β· MNAMS 10+ Years Experience
Common Questions

Patients Ask, Dr. Sumit Answers

Is this safe? Will there be any reaction? +
PRP and BMAC use YOUR OWN cells β€” there is no risk of rejection or allergic reaction. MFAT also uses your own fat. Allogenic therapy uses cells that are immunoprivileged. All procedures are minimally invasive, done in a sterile environment under image guidance. Side effects are limited to mild soreness for 2-3 days at the injection site.
How long before I see results? +
PRP: First signs of improvement at 4-6 weeks. Maximum benefit at 3-6 months. BMAC/MFAT: Gradual improvement over 3-6 months. Unlike cortisone (fast but temporary), regenerative therapy works slowly but creates lasting repair. Be patient β€” the biology takes time.
Will this cure my arthritis? +
Regenerative therapy does not cure arthritis β€” it slows progression, reduces pain, and can repair cartilage damage. Think of it as turning down the volume on the disease and giving the joint a better environment to function. Grade 4 bone-on-bone arthritis cannot be reversed β€” replacement is the appropriate answer there. I will always tell you honestly what your specific situation warrants.
My doctor said I need knee replacement β€” should I get a second opinion? +
Absolutely yes, if you have Grade 1-3 arthritis. Many patients are told they need replacement when they still have viable non-surgical options. Bring your X-ray and MRI to a consultation. I will assess your grade honestly and tell you whether regenerative treatment is appropriate for you β€” or whether surgery genuinely is the right answer.
Can I avoid surgery completely? +
For Grade 1-3 OA β€” in many patients, yes. For Grade 4 bone-on-bone β€” typically no, but we always try regenerative options first if there is any viable remaining cartilage. The window for joint preservation is Grade 1 to 3. Come early β€” do not wait until Grade 4.
How much does it cost? +
Costs vary depending on the procedure β€” PRP is the most affordable, BMAC and MFAT cost more. Allogenic therapy is the most expensive. In every case, I will explain the cost clearly before proceeding, and always give you the realistic expected benefit so you can make an informed decision. Please contact the clinic for current pricing.

Find Out If You Are a Candidate

Bring your X-ray. We will assess your arthritis grade, explain all treatment options honestly, and give you a clear recommendation. No pressure. No unnecessary procedures.

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